Category Archives: News

New drug could slow tumour regrowth in inoperable bowel cancer.

Adavosertib found to delay tumour growth in some patients in clinical trial, with few side effects

Researchers have identified a potential new targeted treatment for incurable bowel cancer.
The medication has shown promise in a clinical trial in slowing the regrowth of tumours among some patients with the condition.
The trial looked at whether a drug called adavosertib, taken as a daily pill, could delay tumour regrowth among patients with an aggressive sub-type of inoperable bowel cancer who have limited treatment options. Researchers compared 44 patients who took adavosertib with 25 patients who did not. They found that the drug delayed tumour growth by about two months on average and had relatively few side effects.

The drug had more effect in the 31 patients with left-sided/rectal tumours, increasing overall survival – meaning patients lived longer.
The lead author, Dr Jenny Seligmann, of the University of Leeds, said: “These results show promising signs that adavosertib may be effective in delaying regrowth of bowel cancer in some patients and is well tolerated.
“The findings are particularly encouraging as the subset of patients involved represent a third of all bowel cancer patients and, while other patients have treatments developed specifically for their tumour types, this group currently has very limited treatment options.”
The scientists caution that larger trials are needed to establish whether the drug improves survival compared with standard treatment.
The drug was trialled among patients on a treatment break after chemotherapy.

However, the research suggested adavosertib could benefit patients with other types of bowel cancer or alongside standard treatments in other lines of therapy. The subset of patients who took part in the trial had tumours with two common mutations, RAS and TP53. Scientists hypothesised these mutations would make the tumours more sensitive to the drug.
According to researchers, about a third of colorectal cancer patients have tumours with these two mutations.

In the UK more than 42,000 people are diagnosed with bowel cancer every year. It is the fourth-most common cancer in the UK and the second-biggest cancer killer.

The findings come from a large collaborative UK trial called Focus4 which aimed to investigate the best ways to help people with inoperable bowel cancer who have already received some chemotherapy. Co-author Prof Louise Brown, from the Clinical Trials Unit at UCL and statistical lead for the Focus4 trial, said: “The results for the adavosertib arm of the trial are potentially important and represent a glimmer of hope for patients in this group.”

Adavosertib kills cancer cells by inhibiting a protein that helps to regulate the process of cell division in the tumour.
Side-effects included fatigue, diarrhoea, neutropenia (involving low levels of white blood cells called neutrophils) and nausea, but none occurred in more than 11% of patients.

A second study from a separate part of the Focus4 trial called Focus4-N, also published in the Journal of Clinical Oncology, looked at outcomes among patients who had a complete break from treatment after chemotherapy.
They were compared with outcomes among those who continued chemotherapy using a simpler tablet called capecitabine.
Researchers found that, among those who had a complete break, the cancer started to grow sooner than in those on continued maintenance therapy.
But that maintenance therapy did not lead to an increase in how long people lived, the study suggested.

The Focus4 trial is funded by the EME Programme – an MRC/NIHR partnership – and Cancer Research UK and is run from the MRC Clinical Trials Unit at UCL in collaboration with Oxford University, Leeds University and Cardiff University.

C-Side Newsletter

C-Side can’t meet as a group, there’s nowhere to go! But we do have a Newsletter in hand. Click on the link to download the October edition:-

 

Bowel Cancer Awareness Event in Brighton – April 6th 2019

Many of you reading this, either yourself or someone you know, will have been affected by colorectal cancer. Either directly or indirectly, you will have experience of the presentation of symptoms and the subsequent diagnosis and treatment of a worrying disease. You will know, but many others may not, that despite Bowel Cancer being the second biggest UK’s killer cancer it is eminently treatable and curable, especially when diagnosed at an early stage.

It is vital, then, for the general good that the public become aware of Bowel Cancer symptoms – some of the more common amongst which include:

  • Bleeding from the bottom and blood in poo
  • Persistent and unexplained change in bowel habit
  • Sudden and unexplained weight loss
  • Being easily fatigued with no obvious reason or cause
  • Pain or a lump in the tummy

April has been set aside nationally to educate the public and raise awareness of these symptoms. Bowel Cancer UK have taken the lead in this and have a variety of educational and awareness programmes set up for April, this link shows their strategy.

For its part C-Side (being representative of Bowel Cancer patients in the Brighton area) felt that there might be more that could be done locally. So, in association with Albion in the Community (AITC), Macmillan Horizon Centre and Bowel Cancer Screening & Colorectal Nurse Specialists from the Royal Sussex University Hospitals, we decided to present a Bowel Cancer Awareness Event here in Brighton. The management from ASDA supermarket in Hollinbury have kindly offered the use of their foyer where we (volunteers and clinical experts) will be on hand to answer questions from the general public on matter related to Bowel Cancer, with the particular objective of educating them in identifying the symptoms listed above, should they ever arise. The event, on Saturday 6th April 2019, will take place from about 10.00 a.m. to 5 p.m.

Macmillan Coastal Garden Trail – 28th/29th July 2018

Take part in the 7th Coastal Garden Trail to raise money for Macmillan’s Horizon Centre.

Driftwood Fundraising Group is holding the 2018 trail on the weekend of 28 and 29 July. Popular gardener, Jim Buttress, will open the trail at 11am at Driftwood in Seaford on the 28 July. Click on the image to find out more on the important event taking place on our Sussex doorstep.

Now, these are all going to be fantastic and C-Side wouldn’t want to promote any particular garden – but you might want to have a look at Annelise’s poster.

Cancer Health & Wellbeing Event at the AMAX

On Tuesday 21st November Albion in the Community (AITC), B&H CCG, staff from BSUH, the Macmillan Horizon Centre and many more are bringing you an event where all local people living with or after cancer can find out about the wide range of support and services available to you, your family, friends and carers.

The morning is given over to all those involved in the provision of support and services where they showcase what they can offer you. The afternoon runs two concurrent streams of expert presentations which you can choose between.

Click on this to see the event programme in greater detail.

Attendance at the event is entirely free and includes lunch and refreshment. The Brighton Bus Company are even offering a number of free tickets. Remember that this event is open to all those affected by cancer and in need of help and advice, this includes family, friends and carers as well as patients.

You must register soon so don’t delay;
phone 1273 668591 or sign up via this link.

 

News from Jane Viner of Macmillan

 

 

Nordic Healthwalkers Course

Limited spaces left …

 Nordic Walking for Health, would like to offer you the opportunity to take up Nordic walking for the benefit of your health and well-being on a tailor-made course for people living with cancer.

The Course:-
A beginner course consists of four sessions, each one and a half hours long. Both the course and the specialist poles are provided free of charge to self-help/support group members living with cancer.

Session 1 – 10.30am to 12midday (Bank Holiday) Monday 29 May
Session 2 – 11am to 12.30pm Wednesday 31 May
Session 3 – 11am to 12.30pm Friday 2 June
Session 4 – 11am to 12.30pm Friday 23 June.

The Course will take place in Stanmer Park, Brighton.
This is an ideal location for Nordic walking. It is easy to get to by car, on local bus routes and near a railway station. Refreshments can be purchased in Stanmer village and toilets are available.

Once the beginner course is complete there will be the opportunity for a group to be formed, so that you can meet together on a regular basis for Nordic walks in the supportive company of like-minded people who have been through similar experiences.

How to register interest?
Limited places are now available for people living with cancer.

It is important that you are ready to take up this activity before starting a course. Once you have registered interest, you will be asked to complete a Physical Activity Readiness Questionnaire and, if necessary, to consult the appropriate healthcare professional for their approval before being offered a place.

To register interest and find out more:
Please contact email peter@nordicwalkingforhealth.co.uk on the subject of Nordic Healthwalking Cancer Support Group.

CARERS WEEK
Carers Week is taking place from Monday 12th June and Macmillan is taking the opportunity to raise awareness of the support and information that is available to carers.

As part of this we are keen to share the experience of carers to help others who may not be aware of support available or indeed identify as carers themselves. If you are caring for somebody affected by cancer and interested in sharing your experience to help raise awareness, we would love to hear from you.

If you are interested, please do contact Charlotte Littlejones, Senior Communications Lead for the South East on clittlejones@macmillan.org.uk
Mobile: 07801 307031.

With kind regards

Jane

Jane Viner
Macmillan Engagement Coordinator – South East
Email: jviner@macmillan.org.uk 
Telephone: 07790 015 448

Administrator for South East Service Development Team
Email: south&eastadmin@macmillan.org.uk
Telephone: 01904 756 463
Address: Macmillan Cancer Support, 3 Fawcett Street, York, YO10 4AH

Rotary Club of Seaford Martellot.

collage1C-Side was delighted to be invited to attend the 28th November meeting of the Rotary Club of Seaford Martello. Ernie Milner & Denise Savage described the work we do, the way we do it and the results we hope to achieve. At the end of the discussion the club President Jackie Arkwell presented C-Side with a cheque for £150 for the purchase of design software to assist C-Side’s publicity and information programme. Denise & Ernie would like to thank Jackie, the Club secretary Dave Winsor and indeed all the members present for their warm welcome and kind attentiveness.

Stop Press ….. Moving On Living Well – 2016!

Building on the success of the Moving On Living Well event in July last year, plans are afoot to repeat the exercise. Remember that there are 300 new bowel & anal cancer patients who start their treatment each year, it’s important that all patients be able to benefit from what has proven to be a rich and varied source of information and advice. Feedback from last year’s attendees lead us to believe that for many the whole day event was a little on the long side and also that travel distance was, for some, an issue. So rather than have a single all-day event it has been decided to host shorter, more intimate events, repeated at the following three locations and times:-

a) 21st April at the Audrey Emerton Building, from 9.00 to 12.00
b) 10th May at the Euan Keat Education Centre, Princess Royal Hospital, from 9.00 to 12.30
c) 5th July at the new Macmillan Horizon Centre from 1.30 to 4.30 in the afternoon.

This will give delegates greater choices on location and the time of day they would like to attend. We shall be covering the same major topics as last year and are very fortunate that the same speakers, or their close colleagues, have agreed to present their subjects.
Another feature of last year’s event that met with widespread approval was the availability of C-Side patients and carers who provided the sort of help and advice that could only come from those who “have been there”. We are again calling for volunteers from C-Side to step forward to take on these vital ambassadorial roles. Since one of the venues will be the brand-new Macmillan Horizon Centre volunteers will need to be registered with them, we are currently looking at how this will be expedited.

So, please send an email if you would like to volunteer and help make Moving On Living Well – 2016 a great success.

p.s. For those who didn’t attend the event last year, there are some photos on our website; just click here